HELLS regulates chromatin remodeling in liver cancer

Dicky's paper has been published in Hepatology!

In this study, Dicky revealed that overexpression of HELLS increased nucleosome occupancy that obstructed the accessibility of enhancers and hindered the formation of nucleosome-free region (NFR) at transcription start site (TSS). Though this mechanism, up-regulation of HELLS mediated epigenetic silencing of multiple tumor suppressor genes in liver cancer.