Jialing’s paper on FACT complex in oxidative stress response has been published in Gut. Big congratulation!!
In this study, Jialing showed that FACT complex is essential for NRF2-dependent oxidative stress adaptation. Oxidative stress stabilized FACT complex by inhibiting KEAP1 mediated ubiquitination and degradation. Stabilized FACT complex forms a feed-forward loop with NRF2. On one hand, NRF2 acts as a transcriptional factor to promote the transcription of FACT complex. On the other hand, FACT complex facilitates the expression of NRF2 and its down-stream antioxidant genes by serving as a histone chaperone to enable a rapid passage of RNA polymerase during transcriptional elongation. Targeting FACT complex suppressed HCC growth and sensitized HCC to Sorafenib treatment (Shen J et al., Gut 2019 doi: 10.1136/gutjnl-2019-318668).
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